Characteristics of purification of pharmaceutical intermediates

Characteristics of purification of Pharmaceutical Intermediates

Pharmaceutical intermediate purification refers to the synthesis of drugs in some chemical raw materials and products for organic macromolecules. It produces odor in the production process, is insoluble in water, has stable chemical properties, and belongs to the type of waste gas that is difficult to treat. Due to the chemical nature of the purification of biological intermediates, the traditional process of spray, adsorption and photolysis of waste gas can achieve efficient removal, especially its strong odor. So what are the characteristics of pharmaceutical intermediate purification?

First, the technology of adsorption and desorption treatment is adopted for the purification of pharmaceutical intermediates. The solid materials required in the oxidation reaction of pharmaceutical intermediate purification are generally less. They are usually mixed with liquid materials and added to the oxidation reactor. The methods of adding control include flowmeter + control valve, vacuum pumping, diaphragm pump feeding and other waste gases in the Pharmaceutical Workshop. Due to the mixing of many non coexisting factors, exothermic reaction, oxidation and polymerization may be caused in the activated carbon bed. Professional purification of pharmaceutical intermediates is trustworthy.

Second, catalytic combustion treatment catalytic combustion is also a major feature of pharmaceutical intermediate purification technology. The application and research of photocatalyst technology, products and projects are at a fairly advanced level at home and abroad. In particular, our "LHP low temperature plasma + composite photocatalysis industrial waste gas purification device" with low temperature plasma power supply and advanced photocatalysis technology as the core has achieved remarkable results in the treatment of large-scale industrial waste gas, which has been highly praised and recognized by relevant national parties, large chemical enterprises and other users, It fills the technical gap in the treatment of industrial large flow organic waste gas in China.

3. Low temperature plasma treatment low temperature plasma treatment is also a new technology used in the purification of pharmaceutical intermediates in recent two years. The so-called plasma is listed as the four states of matter after the three states of solid, gas and liquid. In the oxidation reaction process of pharmaceutical intermediates, the flow addition control of liquid materials generally includes two parts: flow addition total amount control and flow acceleration control. The flow addition total amount control generally adopts the liquid level control or weighing control of high-level tank. This paper mainly introduces the liquid level control of high-level tank. The electron temperature of non-equilibrium plasma can be tens of thousands of degrees, and ions and neutral ions can be as low as room temperature, that is, the apparent temperature of the system is still very low, so it is called "low-temperature plasma", which is generally produced by gas discharge. The purification of functional pharmaceutical intermediates is playing an increasingly important role.

Pharmaceutical intermediate purification? The working principle of plasma exhaust gas purifier is adopted: plasma is called material form, which is composed of electrons, ions, free radicals and neutral particles. Low temperature plasma organic waste gas treatment equipment uses plasma. A large number of studies and literature reports have shown that ultrasound has been widely used in the field of organic synthesis. It can promote many reactions and has the advantages of short reaction time and high reaction yield.