What is a pharmaceutical intermediate

What is a pharmaceutical intermediate

Concept

The so-called Pharmaceutical Intermediates are actually some chemical raw materials or chemical products used in the pharmaceutical synthesis process. This kind of chemical product does not require a production license for drugs, and can be produced in ordinary chemical plants. As long as it reaches some levels, it can be used for the synthesis of drugs.

Effect

Pharmaceutical production requires a lot of special chemicals. Most of these chemicals were originally produced by the pharmaceutical industry. However, with the deepening of social division of labor and the advancement of production technology, the pharmaceutical industry has transferred some pharmaceutical intermediates to chemical companies for production. Pharmaceutical intermediates are fine chemical products, and the production of pharmaceutical intermediates has become a major industry in the international chemical industry.

In cell biology, the intermediate refers to the middle part of the gradually disintegrating spindle around the equatorial plane in the late stage of cell division, and the surrounding cytoplasm concentration increases, filling the entire equatorial plane.

Fluorinated Pyridines
As of 2012, quinolone antibiotics that have been developed and put into mass production in China mainly include norfloxacin, ciprofloxacin, ofloxacin, enoxacin, lomefloxacin, fleroxacin, etc. Among them, the production of norfloxacin, ciprofloxacin and ofloxacin is the largest, accounting for about 98% of the total production of fluoroquinolones in China.

Quinolones are generally obtained by synthesizing fluoroquinoline compounds from fluorobenzene rings and condensing with piperazine (or methylpiperazine). Due to the rich reserves of fluorite, China is one of the countries with the largest output of fluorinated drugs and intermediates in the world, and more than 80% of fluorinated intermediates are supplied and exported. On the whole, fluorobenzene intermediates developed earlier in China, and the production capacity was generally surplus; Trifluoromethyl intermediates developed late and rapidly; For heterocyclic aromatic compounds, especially fluorinated pyridines, only individual research units and manufacturers in China have the synthesis technology of fluorinated pyridine intermediates. Therefore, fluorinated pyridine intermediates will become one of the main research and development directions of fluorinated intermediates in China in the next few years.